A prototype vaccine has protected monkeys from the coronavirus, researchers reported on Wednesday, a finding that offers new hope for effective human vaccines.

Scientists are already testing coronavirus vaccines in people, but the initial trials are designed to determine safety, not how well a vaccine works. The research published Wednesday offers insight into what a vaccine must do to be effective and how to measure that.

“To me, this is convincing that a vaccine is possible,” said Dr. Nelson Michael, the director of the Center for Infectious Diseases Research at Walter Reed Army Institute of Research.

Continue reading “Prototype Vaccine Protects Monkeys From Coronavirus” →

TUSCALOOSA, Ala. — On a cold, gray winter day, Stephen Secor drove to the outskirts of town to catch up with some old friends. He pulled into the driveway of David and Amber Nelson, who welcomed him into their converted basement, filled with stacks of refrigerator-size, glass-doored cages. Each cage contained a massive snake. Some of the Nelsons’ pythons and boa constrictors were recent adoptions from Dr. Secor’s lab, a few miles to the west at the University of Alabama.

Dr. Secor and Mr. Nelson, a product manager at a local car parts factory, hoisted the snakes one at a time out of their cages.

Continue reading “Eat Rat, Make New Body: Easy Stuff for Pythons” →

The New York Times, May 6, 2020

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All viruses mutate, and the coronavirus is no exception. But there is no compelling evidence yet that it is evolving in a way that has made it more contagious or more deadly.

A preprint study — posted online, but not published in a scientific journal and not yet peer-reviewed — has set the internet afire by suggesting otherwise.

On April 30, a report by a team led by Bette Korber, a biologist at Los Alamos National Laboratory in New Mexico, claimed to have found a mutation in the coronavirus that arose in Europe in February and then rapidly spread, becoming dominant as the virus was introduced into new countries.

Continue reading “Did a Mutation Turbocharge the Coronavirus? Not Likely, Scientists Say” →

The New York Times, May 5, 2020

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A team of scientists has developed an experimental prototype for a fairly quick, cheap test to diagnose the coronavirus that gives results as simply as a pregnancy test does.

The test is based on a gene-editing technology known as Crispr, and the researchers estimated that the materials for each test would cost about $6.

“We’re excited that this could be a solution that people won’t have to rely on a sophisticated and expensive laboratory to run,” said Feng Zhang, a researcher at the Broad Institute in Cambridge, Mass., and one of the pioneers of Crispr technology.

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WASHINGTON — Four months after a mysterious new virus began its deadly march around the globe, the search for a vaccine has taken on an intensity never before seen in medical research, with huge implications for public health, the world economy and politics.

Seven of the roughly 90 projects being pursued by governments, pharmaceutical makers, biotech innovators and academic laboratories have reached the stage of clinical trials. With political leaders — not least President Trump — increasingly pressing for progress, and with big potential profits at stake for the industry, drug makers and researchers have signaled that they are moving ahead at unheard-of speeds.

Continue reading “Profits and Pride at Stake, the Race for a Vaccine Intensifies” →