The New York Times, April 4, 2004

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To imagine a time and place – say, the city of Oxford on a summer day in 1662 – you have to engage not only the mind’s eye and ear but also the mind’s nose. The warm odor of malt and corn flour rises from the boats landing at the wharves along the Thames. The stink of cured fish hanging in fishmongers’ stalls mixes with the soft smell of bread in the bakeries. The smell of manure is everywhere, in the open sewers, on the town common where cows graze, in the streets where horses haul wagons and coaches.

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Our ancestors branched off from those of chimpanzees some six million years ago. Since then, our lineage became human–and distinctly unlike other apes. Figuring out how that difference evolved is one of the grand challenges of biology. Until now, scientists have gotten most of their clues by looking at the fossils of extinct hominids. These fragments of bones only preserve a little information, but it’s not a random smattering of data. It’s more like a scaffolding on which other clues can be fixed, so that a picture of how we became human can gradually emerge. That’s because the changes documented in the fossil record were ultimately created through the evolution of our genome.

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