Science, March 9, 2007
Tyrannosaurus rex, it turns out, had a pretty small genome. A team of American and British scientists estimates that it contained a relatively puny 1.9 billion base pairs of DNA, a little over half the size of our own genome.
The scientists who came up with this estimate—along with estimates for the genomes of 30 other dinosaur species—had no ancient DNA to study. T. rex, after all, became extinct 65 million years ago, and its genome is long gone. Instead, they discovered a revealing correlation: Big genomes tend to be found in animals with big bone cells. By comparing the size of cells in dinosaur fossils to those of living animals, the scientists got statistically sound estimates for the sizes of the dinosaur genomes.