Discover, February 18, 2009
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The long battle between humans and infectious microbes has left its marks all over us.
It shows up most obviously in the way our bodies are constructed. The thousands of species of bacteria that swarm over us cannot penetrate our multilayered skin. Entry points, such as the eyes and nose, are bathed in moisture to help flush out pathogens. The lining of our lungs releases bacteria-killing compounds. Viruses that manage to infect cells are greeted by proteins that attempt to shred them into genetic confetti. Any pathogen that sneaks past all these defenses then faces an army of immune cells, which can devour and destroy the invaders. Immune cells can also manufacture antibodies, which allow them to launch swift attacks if they encounter the same infection elsewhere in the body.
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