I’ve been on something of a microbial jag recently. For my past two columns for the New York Times I’ve explored the creepy biochemical sophistication of bacteria.

First, I took a look at the outbreak of toxic bacteria that shut down Toledo’s water supply a couple weeks ago. A lot of people don’t realize it, but those microbes have been spewing out these toxins for about three billion years–for reasons that scientists are still trying to figure out.

Then I wrote about the chemicals that our own microbiome releases, and the ways they can affect our behavior. Some scientists don’t think those changes are just random side effects. Instead, our microbes may be trying to manipulate us for their own benefit, eating certain foods or getting close to other people (also known as hosts).

Check them out!

Continue reading “Microbes as Poisoners and Puppet Masters” →

I can still remember the shock I felt when I heard about fecal microbiota transplants for the first time. It is not the sort of thing you forget.

At a microbiology conference, a scientist was giving a lecture about the microbiome–the microbes that live harmlessly inside of us. She described one unusual case she was involved in where a doctor named Alexander Khorutsused the microbiome to save a patient’s life. The patient had taken antibiotics for a lung infection. While the drugs cleared that infection, they  also disrupted the ecology of her gut, allowing a life-threatening species of bacteria called Clostridium difficile to take over. The pathogen was causing horrific levels of diarrhea. Khoruts couldn’t stop it, because it was resistant to every antibiotic he tried.

So Khoruts decided to use an obscure method: the fecal transplant. He took some stool from the patient’s husband, mixed it with water, and delivered it to her large intestines like a suppository. In a matter of days she was recovering.

Continue reading “Taking the Yuck Out of Microbiome Medicine” →