The New York Times, January 24, 2022

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As nurses and doctors struggle with a record-breaking wave of Omicron cases, evolutionary biologists are engaged in a struggle of their own: figuring out how this world-dominating variant came to be.

When the Omicron variant took off in southern Africa in November, scientists were taken aback by its genetic makeup. Whereas earlier variants had differed from the original Wuhan version of the coronavirus by a dozen or two mutations, Omicron had 53 — a shockingly large jump in viral evolution.

In a study posted online last week, an international team of scientists further deepened the mystery. They found that 13 of those mutations were rarely, if ever, found in other coronaviruses, suggesting they should have been harmful to Omicron. Instead, when acting in concert, these mutations appear to be key to some of Omicron’s most essential functions.

Continue reading “Omicron’s Radical Evolution”

The New York Times, January 18, 2022 (with Ron DePasquale, Alyssa Lukpat and Grace Ashford)

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A wave of Omicron cases may be cresting in the northeastern United States, but the number of Covid-19 patients is at a record high and climbing, overwhelming hospitals whose staffs have been hollowed out by the coronavirus.

Public health leaders warn that while the number of Americans getting infected every day remains dangerously high, there is no guarantee that the population is building enough natural immunity to hasten the day the virus becomes a manageable part of daily life.

Continue reading “Omicron cases may be peaking in some U.S. states, but Covid is overwhelming hospitals.”

The New York Times, January 11, 2022

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A new study of nearly 70,000 Covid patients in California demonstrates that Omicron causes less severe disease than other coronavirus variants, results that align with similar findings from South Africa, Britain and Denmarkas well as a host of experiments on animals.

Compared with Delta, Omicron infections were half as likely to send people to the hospital. Out of more than 52,000 Omicron patients identified from electronic medical records of Kaiser Permanente of Southern California, a large health system, the researchers found that not a single patient went on a ventilator during that time.

“It’s truly a viral factor that accounts for reduced severity,” said Dr. Lewnard, an epidemiologist at the University of California, Berkeley who was an author of the study, which was posted online on Tuesday and has not yet been published in a scientific journal.

Continue reading “California hospitals find that Omicron causes fewer hospitalizations and shorter stays.”

The New York Times, January 3, 2022 (with Andrew Jacobs)

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What is the Omicron variant?

First identified in Botswana and South Africa in November, the Omicron variant has surged around the world over the past few weeks, faster than any previously known form of the coronavirus. While there’s a lot that scientists have yet to understand about Omicron, the variant is already causing a rise in new cases that may push some hospital systems to the breaking point.

Continue reading “Omicron: What We Know About the New Coronavirus Variant”

The New York Times, December 31, 2021 (with Azeen Ghorayshi)

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A spate of new studies on lab animals and human tissues are providing the first indication of why the Omicron variant causes milder disease than previous versions of the coronavirus.

In studies on mice and hamsters, Omicron produced less damaging infections, often limited largely to the upper airway: the nose, throat and windpipe. The variant did much less harm to the lungs, where previous variants would often cause scarring and serious breathing difficulty.

“It’s fair to say that the idea of a disease that manifests itself primarily in the upper respiratory system is emerging,” said Roland Eils, a computational biologist at the Berlin Institute of Health, who has studied how coronaviruses infect the airway.

Continue reading “Studies Suggest Why Omicron Is Less Severe: It Spares the Lungs”