The New York Times, June 19, 2013

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The laboratory of Vera Gorbunova and Andrei Seluanov, a husband-and-wife team of biologists at the University of Rochester, has the feel of a petting zoo. They maintain colonies of several species of rodents — some familiar, like mice and guinea pigs, and some much more exotic, like blind mole rats from Israel and naked mole rats from East Africa.

Amusing children with furry creatures is not their goal, however. The biology of animals is mysteriously diverse, and lurking within it may be clues to new kinds of medicine.

Continue reading “A Homely Rodent May Hold Cancer-Fighting Clues”

The New York Times, May 31, 2013

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The stories of scientists create new scientists. Alexander von Humboldt — the most famous naturalist of the early 19th century — chronicled his epic expeditions, between 1799 and 1804, in his “Personal Narrative of a Journey to the Equinoctial Regions of the New Continent.” When a nature-loving student at Cambridge named Charles Darwin read the book, it changed his life. He read passages aloud to his professors and learned Spanish so that he could follow in Humboldt’s footsteps.

Continue reading “Apes”

Discover, January 30, 2013

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Ten thousand years ago, there were just 5 million people on Earth, fewer than live in Singapore today. The population has since soared to 7 billion. This rapid growth has left a mark on the human genome, researchers are finding, drastically increasing the number of very rare mutations in our DNA. That realization casts doubt on the long-standing view that just a few genetic mutations underlie many hereditary diseases. In reality, those diseases are probably caused by a wide variety of extremely rare mutations that vary from one person to the next, complicating efforts to understand and treat them at the genetic level.

Continue reading “80. Rare Genes Cause Common Diseases”

The New York Times, April 16, 2012

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Naoki Mori, the Japanese cancer researcher who has had 30 papers retracted by scientific journals, was asked to give his side of the story. In an e-mail, he acknowledged that his colleagues “were lax in certain regards in the preparation of papers,” but he denied having committed a grave offense.

The studies were retracted because they used pictures from older papers, rather than from the experiments described in the studies. “I think this reuse is not a scientific misconduct,” Dr. Mori wrote.

He and his colleagues studied the response of human cells to infection by bacteria and viruses.

Continue reading “After Mistakes, Scientists Try to Explain Themselves”

Discover, September 15, 2011

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For 100 million people around the globe who suffer from macular degeneration and other diseases of the retina, life is a steady march from light into darkness. The intricate layers of neurons at the backs of their eyes gradually degrade and lose the ability to snatch photons and translate them into electric signals that are sent to the brain. Vision steadily blurs or narrows, and for some, the world fades to black. Until recently some types of retinal degeneration seemed as inevitable as the wrinkling of skin or the graying of hair—only far more terrifying and debilitating. But recent studies offer hope that eventually the darkness may be lifted.

Continue reading ““I See,” Said the Blind Man With an Artificial Retina”