The Future Of Aging

Carl Zimmer hosts the latest season of “The World As You’ll Know It,” a podcast about the future of science and technology. Across seven episodes, he explores the science of aging–how we’ve added three decades to human life expectancy over the past century, how new discoveries about the biology of aging could lead to new ways to extend it even more, and how society needs to change to catch up with the revolution in longevity.

New episodes come out each Tuesday. Subscribe on Apple, Spotify, Pocket Casts or wherever you listen to podcasts!

The Billion Dollar Bet: Will Humans Live to 150?

In 2000, two scientists — Steve Austad, a biologist and Jay Olshanksy, a demographer — made a bet. Would a  person live to the age of 150 by the year 2150? Austad bet yes and Olshansky bet no. They put up $150, fittingly enough. By the time the bet comes due, the wager will have increased to a billion dollars. In this episode, we revisit this twenty-five year old bet  to find both men sticking to their guns. We also  speak to  Nobel Prize winner, Venki Ramakrishnan, about new insights into what causes us to age. The episode explores the latest science around aging to expose two competing ways of understanding the human lifespan. Are we locked into a hard age limit established by centuries of data? Or could a scientific breakthrough push us far beyond it so that many of us will live decades longer? 

The Truth About Biohacking

Blood transfusions, experimental drugs and intermittent fasting are just a few of the measures so-called biohackers are taking in hopes of radically extending their lifespans. But what started as a faddish subculture has boomed into a multi-billion dollar industry – encompassing both shady claims and reputable scientific research. In this episode, we unpack the science and the hype behind some of the most prominent biohacking tools being used today, including caloric restriction, Rapamycin, and Metformin with Dr. Venki Ramakrishnan, the Nobel Prize-winning biochemist. We also speak with Dr. Daniel Belsky, the inventor of a blood test that can reveal how fast your body is aging, which could expedite testing on potentially life-extending treatment.

We’re Underestimating Older Brains

A forgotten name, misplaced keys, feeling overwhelmed by some new technology. Classic signs of a brain beginning its long, inexorable descent into old age? Not necessarily. In fact, new research shows that we can preserve and even enhance our cognitive skills as we get older.

Why Haven’t We Solved Alzheimer’s?

We’ve known about Alzheimer’s and its devastating effects for more than 100 years, and have been predicting an imminent cure for at least the last 25. So why is it that after so many years of research and unrelenting loss, we’re not further along in our progress towards a cure? In this episode we consult three experts who have dedicated much of their lives to understanding this question. Neurobiologist Karl Herrup is the author of “How Not To Study a Disease: The Story of Alzheimer’s.” Charles Piller is a journalist who spent years researching the scandals that recently rocked the Alzheimer’s community. Donna Wilcock is a neurologist who has been studying Alzheimer’s disease and other forms of dementia for decades, and is also the editor-in-chief of the official journal of the Alzheimer’s Association. Together they help explain where we went wrong, and suggest where we might look next in our search for a cure.

Why Women Live Longer than Men

Women tend to live longer than men, even under the most difficult conditions like famines and epidemics. While it’s true that women tend to go to the doctor more and engage in less risk-prone activities, behavior alone doesn’t explain this phenomenon. In this episode, demographer Virginia Zarulli tells us about the implications of the startling fact that, in times of extreme hardship, it is often infant girls outliving infant boys that contributes most to the gap in longevity. Neurologist Dena Dubal, who has spent years studying the influence of the second X chromosome that females carry, explains how research into how women age will benefit men, too. And neuroscientist Lisa Mosconi talks about the impact of sex hormones on aging and why women are disproportionately susceptible to certain age-related diseases.