Happy March! Here’s a late-winter selection of updates…


Doubling DNA, Twins CSI, and Mice in Conversation

Since the last Friday’s Elk, I wrote three pieces for the New York Times on three rather different topics.

1. Your DNA is spelled out in an alphabet of four “letters.” Now scientists have added another four, and found that this new eight-letter DNA can still work as a way to store genetic information. Perhaps we will use this molecule to store movies and spreadsheets someday. Leading the effort is a scientist named Steven Benner. You can listen to Benner and me talk about just how weird life can get in this episode of my podcast, “What Is Life?”

2. Identical twins are not exactly identical, even though they descend from a single fertilized egg containing a single genome. Mutations arise in embryos as their cells divide, and when twin embryos split apart, one may end up with a few mutations that the other lacks, and vice versa. Forensic scientists have wondered for many years if a DNA test could ever tell twins apart. I tell the story of the long search for such a test–and puzzle over why it isn’t being used right now to solve cold cases.

3. Our power of language may be one of the most important features that sets our species apart from all other living things. But language’s building blocks may have been evolving for 100 million years. I write about a strange singing mouse that seems to communicate in conversations–and uses some of the same brain circuitry we use to do so. (Mouse photo by Christopher Auger-Dominguez)


What’s In Your Genome?

The newest episode of Radiolab takes a look at that bizarre attic that is our genome. I talked with producer Pat Walters about some of the junk that, with a little evolutionary altering, has become downright useful–even essential. Take a listen. (Here’s a story I wrote for the New York Times Magazine about junk DNA, and here’s a blog post I wrote about the viral gene without which none of us would be born.)

By coincidence, a couple other podcasts have just posted interviews about She Has Her Mother’s LaughPoint of Inquiry and Curiosity Daily.

Cold, Hot, Cold

As spring approaches, I’m starting to scramble again, traveling hither and yon to give talks. This past week, I headed to snowy Cambridge, Mass., for a conversation with David Quammen, then journeyed to the sultry city of Adelaide in Australia for their writers festival, and finally returned to the snow to give a lecture at the University of Illinois.

Here is a nice write-up in the Harvard Gazette of my conversation with Quammen about the tree of life, writing about nature, and more. The video will be available within a few weeks; I will keep you posted.

 

From Bellybuttons to the Roman Empire

Tim Flannery, an Australian biologist and author of many fine books, wrote a gratifying review of She Has Her Mother’s Laugh for the New York Review of Books. (First time I’ve been reviewed in their pages!)

Snip:

“A grand and sprawling book that investigates all aspects of inheritance, from ancient Roman law to childhood learning, and on to the bacteria that inhabit our belly buttons (which are surprisingly varied among individuals). Along the way, the book provides many amusing historical anecdotes and important scientific insights…Some of the most fascinating material Zimmer covers concerns the phenomena of mosaicism and chimerism, in which individuals are made up of cells with differing genetic inheritances.”

 

Upcoming Talks
More talks coming soon…

March 15, 2019 Brookline, MA.“Science On Screen” at the Coolidge Theater. (A double-feature: a talk about heredity and a screening of the heredity-based comedy, Flirting With Disaster.)

April 9, 2019 Wellesley College. Mayer Lecture. Details to come.

May 25-26, 2019 Copenhagen: Bloom Festival.

If you’ve enjoyed reading She Has Her Mother’s Laugh, please rate/review it on your favorite book site, such as Goodreads or Amazon. Thanks!

You can find information and ordering links for my other books here. You can also follow me on TwitterFacebookGoodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl

Originally published March 8, 2019. Copyright 2019 Carl Zimmer.

The New York Times, March 1, 2019

Link

One night in November 1999, a 26-year-old woman was raped in a parking lot in Grand Rapids, Mich. Police officers managed to get the perpetrator’s DNA from a semen sample, but it matched no one in their databases.

Detectives found no fingerprints at the scene and located no witnesses. The woman, who had been attacked from behind, could not offer a description. It looked like the rapist would never be found.

Five years later, there was a break in the case. A man serving time for another sexual offense submitted a DNA sample with his parole application. The sample matched DNA from the rape scene.

Continue reading “One Twin Committed the Crime — but Which One? A New DNA Test Can Finger the Culprit”

The New York Times, February 28, 2019

Link

High in the mountains of Central America lives a little known creature called Alston’s singing mouse. This rodent, which spends its life scuttling around the floor of the cloud forest, may not seem like it has much to tell us about ourselves.

But the mouse produces remarkable songs, and researchers have discovered some profound similarities to our own conversations. This ability may be linked evolutionarily to the ancient roots of human language.

Scientists have struggled for over a century to work out the origin of language in our mammal ancestors.

Continue reading “These Mice Sing to One Another — Politely”

The New York Times, February 21, 2019

Link

In 1985, the chemist Steven A. Benner sat down with some colleagues and a notebook and sketched out a way to expand the alphabet of DNA. He has been trying to make those sketches real ever since.

On Thursday, Dr. Benner and a team of scientists reported success: in a paper, published in Science, they said they have in effect doubled the genetic alphabet.

Natural DNA is spelled out with four different letters known as bases — A, C, G and T. Dr. Benner and his colleagues have built DNA with eight bases — four natural, and four unnatural. They named their new system Hachimoji DNA (hachi is Japanese for eight, moji for letter).

Continue reading “DNA Gets a New — and Bigger — Genetic Alphabet”

New Year, New Podcast

For the first Friday’s Elk of 2019, I have some good news. In some earlier newsletters I wrote about a live series of conversations I hosted in New York about the nature of life itself. Now you can listen to the podcast edition of “What Is Life?”–eight episodes of talk with fascinating thinkers about what it means to be alive. Here’s a link to iTunes. Also I’ve put together a page on my web site with show notes and embedded recordings, plus a set of pages on Medium. It should also be propagating itself to Sticher and other podcast services. Thanks to Ben Lillie and all the good people at Caveat for making this happen!

Decoding Watson

PBS recently ran a thorough and provocative documentary about Jim Watson, who shared the Nobel Prize for discovering the structure of DNA. You can watch it here. I show up from time to time to offer some talking-head narration. For more on the show, you can read this New York Times article by Amy Harmon–and her follow-up piece on the fall-out that ensured after the show aired.

CRISPR on The Daily

Jennifer Senior interviewed me about the ongoing CRISPR baby saga for the Daily podcast from the New York Times. Listen here.

Crickets and Spies

Here’s what I’ve been writing for the New York Times since the last Friday’s Elk:

1. Numerous remains of Aboriginal Australians are scattered in museum collections around the world. DNA may help bring them back home to rest.

2. In Cuba, American diplomats have suffered mysterious neurological symptoms. One common report was that they heard strange sounds before falling ill. Was it a sonic weapon–or Cuban crickets?

3. There’s evidence suggesting that our microbiome is talking to our brains. And that conversation may have an influence on the development of conditions ranging from Alzheimer’s to autism. For this feature, I tried to balance the excitement of the science with the profound mysteries that remain. Don’t expect a quick probiotic cure for Parkinson’s any time soon.

4. A quarter million years of Denisovan history. The Denisovans are an extinct branch of the human family, known only from a single Siberian cave. Now their fossils have a clear-cut timeline. They lived in the cave for at least 250,000 years and may have gained the powers of self-expression along the way.

New to the Calendar

A couple updates to my upcoming appearances:

If you’re heading to the annual AAAS meeting in Washington DC, please consider coming to my lecture on Saturday at noon. I’ll be signing books afterwards.

I’m looking forward to a live conversation with David Quammen at Harvard on February 28.

Upcoming Talks

February 16, 2019 Washington DC AAAS Topical Lecture: “Heredity: Our Defining Mystery”…followed by a book signing.

February 20, 2019 Connecticut College, New London CT: “The Deep History of Global Affairs”

February 28, 2019 Harvard Museum of Natural History: A Conversation with David Quammen.

March 3, 2019 Adelaide Writer’s Week

March 7, 2019 University of Illinois, Urbana-Champaign. Thomas M. Siebel Lecture Series in Science and Society. Details to come.

March 15, 2019 Brookline, MA. “Science On Screen” at the Coolidge Theater. (A double-feature: a talk about heredity and a screening of the heredity-based comedy, Flirting With Disaster.)
April 9, 2019 Wellesley College. Mayer Lecture. Details to come.

May 25-26, 2019 Copenhagen: Bloom Festival. Details to come.

 

If you’ve enjoyed reading She Has Her Mother’s Laugh, please rate/review it on your favorite book site, such as Goodreads or Amazon. Thanks!

You can find information and ordering links for my other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl

Originally published January 31, 2019. Copyright 2019 Carl Zimmer.