The New York Times, September 11, 2019

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Twenty years ago, the fight against cancer seemed as if it were about to take a dramatic turn.

Traditionally, cancer doctors fought the disease with crude weapons, often simply poisoning fast-growing cells whether they were cancerous or healthy. But then a team of researchers hit on a new strategy: drugs targeting proteins produced by cancer cells that seemed necessary to their survival.

One such drug, Gleevec, worked spectacularly in patients with chronic myeloid leukemia. But the clinical trials that followed mostly have produced disappointments.

Continue reading “Why Aren’t Cancer Drugs Better? The Targets Might Be Wrong” →

The New York Times, September 10, 2019

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A single new fossil can change the way we think about human origins, but discovering it — deep in a cave or buried in rock — remains a daunting struggle for hammer-wielding paleoanthropologists.

“It can take years and luck to find the right one,” said Aurélien Mounier, a paleoanthropologist at the French National Museum of Natural History.

Now researchers like Dr. Mounier are using computers and mathematical techniques to reconstruct the appearance of fossils they have yet to find.

Continue reading “Scientists Find the Skull of Humanity’s Ancestor, on a Computer” →

The New York Times, August 29, 2019

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SAN DIEGO — Two hundred and fifty miles over Alysson Muotri’s head, a thousand tiny spheres of brain cells were sailing through space.

The clusters, called brain organoids, had been grown a few weeks earlier in the biologist’s lab here at the University of California, San Diego. He and his colleagues altered human skin cells into stem cells, then coaxed them to develop as brain cells do in an embryo.

The organoids grew into balls about the size of a pinhead, each containing hundreds of thousands of cells in a variety of types, each type producing the same chemicals and electrical signals as those cells do in our own brains.

Continue reading “Organoids Are Not Brains. How Are They Making Brain Waves?” →

The New York Times, August 22, 2019

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A previously unknown outbreak of the Zika virus swept across Cuba in 2017, a year after the global health emergency was declared over, scientists reported on Thursday.

Until now, the Pan American Health Organization had no record of any Zika infection in Cuba in 2017, much less an outbreak. Following inquiries by The New York Times about the new study, published in the journal Cell, officials acknowledged that they had failed to tally 1,384 cases reported by Cuban officials that year.

That figure is a sharp increase over the 187 cases confirmed in 2016 and is “in line with the estimates for 2017 from our own study,” said Kristian Andersen, an infectious disease researcher at Scripps Research Translational Institute in La Jolla, Calif., and a co-author of the new study.

Continue reading “Zika Was Soaring Across Cuba. Few Outside the Country Knew.” →