Uta Frith, a world expert on autism, has listed Soul Made Flesh as one of her favorite books about the mind over at the web site Five Books:

I admire communicators who tell you about complex matters, which you would otherwise have little hope of learning about. I write scientific books so I understand how difficult it is. This book is a book about science and at the same time a book about history, and I love reading about the history of science. Here he writes about the beginnings of the Royal Society in the 17th century.

Thomas Willis is the main hero of the book. He was a doctor who began studying the brain itself in the turbulent time of the Civil War. Christopher Wren, famed for building St Paul’s Cathedral after the Great Fire of London, did some beautiful anatomically accurate drawings of the brain, which was interesting to find out about. And you have the astonishing idea that the brain produces the mind — and in Zimmer’s words, the soul is made flesh — which even today many people find hard to accept.

What I like about this book is that it is not just about the early history of how people came to study the brain, but it is also about recent brain science, where scanners are used to watch what happens in the brain while it is thinking. One of the ideas he tells about is some research I myself was involved with, the brain’s “Theory of Mind”. It is a strange concept, which is historically linked with autism. This is the idea that one of the fundamental problems in autism is an inability to understand that other people have minds that explain and predict their behaviour. And I find Zimmer’s account very interesting. We need to find out how the mind can go wrong in such a way that autism results and what it is that stops the ability to socially interact and communicate.

Check out her other four picks here.

Originally published June 16, 2010. Copyright 2010 Carl Zimmer.

In honor of the tenth anniversary of the human genome project, here are a couple telling images, courtesy of Mihaela Pertea and Steven L Salzberg.

First: a visual history of the estimates of the number of genes in the human genome.
And second, a warning to anyone who believes in an iron law that the more protein-coding genes in a species, the more sophisticated/complex/cool/human that species is: I for one welcome our grapey overlords.

[Update: Biochemist Larry Moran takes issue with the very high numbers for early gene number estimates. Steven Salzberg defends the graph. Read it all here!]

Originally published June 15, 2010. Copyright 2010 Carl Zimmer.

Discover, June 15, 2010

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This month’s column is a tale of two rats. One rat got lots of attention from its mother when it was young; she licked its fur many times a day. The other rat had a different experience. Its mother hardly licked its fur at all. The two rats grew up and turned out to be very different. The neglected rat was easily startled by noises. It was reluctant to explore new places. When it experienced stress, it churned out lots of hormones. Meanwhile, the rat that had gotten more attention from its mother was not so easily startled, was more curious, and did not suffer surges of stress hormones.

Continue reading “Brain switches that can turn mental illness on and off”

Ariel writes, “I am happy to see that other science dorks like myself have inked up our passions. This is the molecular representation of glutamic acid, the amino acid associated with the Umami flavor, the proverbial fifth taste. I am a former chef turned public health major and fell in love with the elegance of chemical compounds but never forgot my unctuous roots.

Click here to go to the full Science Tattoo Emporium.

Originally published June 12, 2010. Copyright 2010 Carl Zimmer.