The New York Times, August 21, 2012

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People have been searching for new medicines for thousands of years, and yet we have barely explored the universe of possibilities. Recently chemists at the University of Bern in Switzerland tried to estimate how many promising molecules have yet to be tested. In June they published their best guess: over a million billion billion billion billion billion billion. Blindly testing those molecules one at a time is not practical, and most of them will turn out to be useless anyway. So many scientists are looking for strategies they can use to zero in more quickly on promising candidates.

Continue reading “Gene Tests in Yeast Aid Work on Cancer”

In today’s New York Times, Manny Fernandez and Donald McNeil report that West Nile virus is wreaking havoc in Dallas. This summer, 200 people have become ill in Dallas County, and 10 people have died so far. Those are worryingly high numbers in a single Texas county of 2.4 million people, and so Dallas has declared a state of emergency. The city is now swept up in a debate about the safety of widespread pesticide spraying to kill off mosquitoes, which carry the virus. Fernandez and McNeil quote public health experts who warn that it’s probably a harbinger of things to come throughout the country this year.

For many young people in the United States, West Nile virus has been a fact of life for as long as they can remember. But before 1999, there was no West Nile virus in this country. None. Its arrival and its spread are a sobering lesson in how quickly diseases can establish themselves.

To offer some background to today’s news, I am reprinting an essay from my 2011 book, A Planet of Viruses, about how West Nile came to America. Continue reading “West Nile Virus: The Stranger That Came To Stay”

I have been meaning to read a book coming out soon called Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. It’s written by Harvard biologist George Church and science writer Ed Regis. Church is doing stunning work on a number of fronts, from creating synthetic microbes to sequencing human genomes, so I definitely am interested in what he has to say. I don’t know how many other people will be, so I have no idea how well the book will do. But in a tour de force of biochemical publishing, he has created 70 billion copies. Instead of paper and ink, or pdf’s and pixels, he’s used DNA.

Continue reading “Want to Get 70 Billion Copies of Your Book In Print? Print It In DNA”

This post was originally published in “Download the Universe,” a multi-author blog about science ebooks edited by Carl Zimmer.

Deep Water: As Polar Ice Melts, Scientists Debate How High Our Oceans Will Rise. By Daniel Grossman. Published by TED Books, 2012.

Guest reviewed by John Dupuis

August 15, 2012

Continue reading “Deep Water: A Pretty Good TED Ebook (Really!) About Climate Change”

Slate, August 14, 2012

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As a young biologist, Elizabeth Iorns did what all young biologists do: She looked around for something interesting to investigate. Having earned a Ph.D. in cancer biology in 2007, she was intrigued by a paper that appeared the following year in Nature. Biologists at the University of California-Berkeley linked a gene called SATB1 to cancer. They found that it becomes unusually active in cancer cells and that switching it on in ordinary cells made them cancerous. The flipside proved true, too: Shutting down SATB1 in cancer cells returned them to normal. The results raised the exciting possibility that SATB1 could open up a cure for cancer. So Iorns decided to build on the research.

There was just one problem. As her first step, Iorns tried replicate the original study. She couldn’t. Boosting SATB1 didn’t make cells cancerous, and shutting it down didn’t make the cancer cells normal again.

Continue reading “Good Scientist! You Get a Badge.”