The New York Times, August 21, 2012
People have been searching for new medicines for thousands of years, and yet we have barely explored the universe of possibilities. Recently chemists at the University of Bern in Switzerland tried to estimate how many promising molecules have yet to be tested. In June they published their best guess: over a million billion billion billion billion billion billion. Blindly testing those molecules one at a time is not practical, and most of them will turn out to be useless anyway. So many scientists are looking for strategies they can use to zero in more quickly on promising candidates.