The New York Times, February 5, 2015

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In the closing sentence of “The Origin of Species,” Charles Darwin marvels at the process of evolution, observing how “from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.”

Few people would describe bedbugs as most beautiful or most wonderful. Yet this blood-feeding pest may represent an exceptional chance to observe the emergence of Darwin’s “endless forms”: New research indicates that some bedbugs are well on their way to becoming a new species.

Continue reading “In Bedbugs, Scientists See a Model of Evolution”

FORTY MILLION YEARS AGO, VIRUSES INVADED THE GENOMES OF ANCIENT PRIMATES. TODAY, WE SHARE SOME OF THAT VIRAL DNA IN COMMON WITH BABOONS. PHOTO BY RUSS POLLACK VIA CREATIVE COMMONS

Each year, billions of people get infected with viruses–with common ones like influenza and cold viruses, and rarer ones like polio and Ebola. The viruses don’t stay all that long inside of us. In most cases, our immune systems wipe them out, except for a few refugees that manage to escape to a new host and keep their species alive. In some cases, the viruses kill their unfortunate hosts, and end their own existence as well. But in some exquisitely rare cases, viruses meld with the genome of their hosts and become part of the genetic legacy their hosts pass down to future generations.

Continue reading “Our Inner Viruses: Forty Million Years In the Making”

Scientific American, January 31, 2015

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At the University of Zurich, Rolf Kümmerli investigates new drugs to stop deadly infections. He spends his days in a laboratory stocked with petri dishes and flasks of bacteria—exactly the place where you would expect him to do that sort of work. But Kümmerli took an odd path to get to that lab. As a graduate student, he spent years hiking through the Swiss Alps to study the social life of ants. Only after he earned a Ph.D. in evolutionary biology did he turn his attention to microbes.

The path from ants to antibiotics is not as roundabout as it may seem.

Continue reading “Experimental Drugs Target Bacteria’s Social Network”

DIVIDING LUNG CANCER CELL. PHOTO BY ANNE WESTON, LRI, CRUK, WELLCOME IMAGES

Biologists who study cancer have been borrowing a lot of concepts from evolution in recent years. That’s because the changes that occur inside a tumor bear some striking resemblances to what natural selection does to a population of animals, plants, or bacteria. Evolutionary biologists who study societies–from human tribes to ant colonies–have investigated how cooperation can evolve when cheating can let some individuals get ahead. Now scientists are finding evidence of cooperation and cheating among cancer cells. In my column this week for the New York Timesmy column this week for the New York Times, I look at the social life of cancer–and how we might undermine it to fight the disease.

This video, made by the authors of a new study I write about in the column, presents the gist of this idea–of killing a tumor by creating a new tumor inside of it.

Continue reading “The Tumor Within A Tumor”

The New York Times, January 29, 2015

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A tumor, as strange as it may sound, is a little society. The cancer cells that make it up cooperate with one another, and together they thrive.

Scientists are only starting to decipher the rules of these communities. But if they can understand how these cells work together, then they may be able to stop the tumor. “You can drive it to collapse,” said Marco Archetti, a biologist at the University of East Anglia and at the Icahn School of Medicine at Mount Sinai.

Cancer starts when healthy cells mutate and lose the safeguards that normally keep their growth in check. The cells start to multiply quickly, and their descendants gain new mutations, some of which make the cells even better at multiplying.

Continue reading “In the Way Cancer Cells Work Together, a Possible Tool for Their Demise”