Discover, April 14, 2009

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There is nothing more humbling or more perception-changing than holding a human brain in your hands. I discovered this recently at a brain-cutting lesson given by Jean-Paul Vonsattel, a neuropathologist at Columbia University. These lessons take place every month in a cold, windowless room deep within the university’s College of Physicians and Surgeons. On the day I visited, there were half a dozen brains sitting on a table. Vonsattel began by passing them around so the medical students could take a closer look. When a brain came my way, I cradled it and found myself puzzling over its mirror symmetry. It was as if someone had glued two smaller brains together to make a bigger one.

Continue reading “The Big Similarities & Quirky Differences Between Our Left and Right Brains”

The New York Times, April 6, 2009

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For its first four weeks, a human embryo looks like a crumpled tube. But around its twenty-seventh day of development, four buds bulge from its sides. Over the next few days, the buds grow like tulips, stretching out into flattened stalks and blooming into crowns of fingers and toes. Inside these developing limbs, bones condense. Muscle cells, tendons, blood vessels and nerves all find their respective places. The embryo now has hands with thumbs to suck, legs ready to deliver a kick.

For developmental biologists, the development of limbs captures all that is marvelous about embryos: how a few cells can give rise to complicated anatomy. In fact, biologists understand the development of the limb much better than any other part of the body.

Continue reading “From Developing Limbs, Insights That May Explain Much Else”

Discover, March 16, 2009

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I was looking forward to my first experience with anesthesia. I had been laid out on a stretcher, and nurses and doctors were prepping my midsection so they could slice it open and cut out my appendix. After a bout of appendicitis, a short vacation from consciousness seemed like a pleasant way to spend a few hours. I had no idea what anesthesia would actually feel like, though, and suddenly I was seized by skepticism. I tried to hoist myself up, already swabbed in iodine, as I suggested that I ought to pop into the men’s room before the scalpels came out. I wouldn’t want to interrupt the surgery with a bathroom break. “Don’t worry,” one of the nurses replied. “We’ll do that for you.”

Continue reading “Could a Dose of Ether Contain the Secret to Consciousness?”

Discover, February 18, 2009

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The long battle between humans and infectious microbes has left its marks all over us.

It shows up most obviously in the way our bodies are constructed. The thousands of species of bacteria that swarm over us cannot penetrate our multilayered skin. Entry points, such as the eyes and nose, are bathed in moisture to help flush out pathogens. The lining of our lungs releases bacteria-killing compounds. Viruses that manage to infect cells are greeted by proteins that attempt to shred them into genetic confetti. Any pathogen that sneaks past all these defenses then faces an army of immune cells, which can devour and destroy the invaders. Immune cells can also manufacture antibodies, which allow them to launch swift attacks if they encounter the same infection elsewhere in the body.

Continue reading “Is Patriotism a Subconscious Way for Humans to Avoid Disease?”

Seed Magazine, February 12, 2009

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A natural history museum is really two museums, and when you’re in one of them, you can hardly imagine the other. I don’t know how many times I’ve wandered around the halls of the American Museum of Natural History, among the armored fish and the stegosaurs. But it wasn’t until I was a 26-year-old science writer that I had the chance to pass through to the other side. I wanted to learn about pterosaurs, those stork-faced, bat-bodied reptiles that soared for 150 million years. I found out about a Brazilian man named Alexander Kellner who was getting his Ph.D. at the museum, studying new fossils of pterosaurs from the Santana Formation. Kellner invited me to the museum, to take a look at the bones and talk about his ideas about what pterosaurs had actually been like in life.

Continue reading “The Awe of Natural History Collections”