Quanta Magazine, February 6, 2015

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On a November evening last year, Jennifer Doudna put on a stylish black evening gown and headed to Hangar One, a building at NASA’s Ames Research Center that was constructed in 1932 to house dirigibles. Under the looming arches of the hangar, Doudna mingled with celebrities like Benedict Cumberbatch, Cameron Diaz and Jon Hamm before receiving the 2015 Breakthrough Prize in life sciences, an award sponsored by Mark Zuckerberg and other tech billionaires. Doudna, a biochemist at the University of California, Berkeley, and her collaborator, Emmanuelle Charpentier of the Helmholtz Centre for Infection Research in Germany, each received $3 million for their invention of a potentially revolutionary tool for editing DNA known as CRISPR.

Continue reading “Breakthrough DNA Editor Born of Bacteria”

MEASLES-INFECTED IMMUNE CELLS (GREEN BLOBS) PASS ON THE VIRUSES TO EPITHELIAL CELLS LINING THE NOSE. PHOTO BY PAUL DUPREX.

Here are two recent stories about viruses. They started out alike, and ended up very differently.

In October, a woman in Guinea died of Ebola, leaving behind two daughters, one of them two years old, the other five. A relative named Aminata Gueye Tamboura  took the orphaned children back to her home in northwest Mali–a 700-mile journey. Tamboura didn’t know it then, but the younger girl, named Fanta Conde, was infected with Ebola as well. For three days, they traveled on buses and in taxis as Fanta grew ill, developing a scorching fever and a perpetual nosebleed. Soon after arriving in Mali, she died.

Yet Tamboura never became infected with Ebola. Nor did Fanta’s sister or her uncle, who also made the trip. Nor did anyone else who shared the buses and taxis with Fanta, or who encountered Fanta elsewhere on her doomed journey. After Fanta’s death, the entire country of Mali braced for a devastating outbreak. But the outbreak never came.

Continue reading “How The Measles Virus Became A Master of Contagion”

The New York Times, February 5, 2015

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In the closing sentence of “The Origin of Species,” Charles Darwin marvels at the process of evolution, observing how “from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.”

Few people would describe bedbugs as most beautiful or most wonderful. Yet this blood-feeding pest may represent an exceptional chance to observe the emergence of Darwin’s “endless forms”: New research indicates that some bedbugs are well on their way to becoming a new species.

Continue reading “In Bedbugs, Scientists See a Model of Evolution”

FORTY MILLION YEARS AGO, VIRUSES INVADED THE GENOMES OF ANCIENT PRIMATES. TODAY, WE SHARE SOME OF THAT VIRAL DNA IN COMMON WITH BABOONS. PHOTO BY RUSS POLLACK VIA CREATIVE COMMONS

Each year, billions of people get infected with viruses–with common ones like influenza and cold viruses, and rarer ones like polio and Ebola. The viruses don’t stay all that long inside of us. In most cases, our immune systems wipe them out, except for a few refugees that manage to escape to a new host and keep their species alive. In some cases, the viruses kill their unfortunate hosts, and end their own existence as well. But in some exquisitely rare cases, viruses meld with the genome of their hosts and become part of the genetic legacy their hosts pass down to future generations.

Continue reading “Our Inner Viruses: Forty Million Years In the Making”

Scientific American, January 31, 2015

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At the University of Zurich, Rolf Kümmerli investigates new drugs to stop deadly infections. He spends his days in a laboratory stocked with petri dishes and flasks of bacteria—exactly the place where you would expect him to do that sort of work. But Kümmerli took an odd path to get to that lab. As a graduate student, he spent years hiking through the Swiss Alps to study the social life of ants. Only after he earned a Ph.D. in evolutionary biology did he turn his attention to microbes.

The path from ants to antibiotics is not as roundabout as it may seem.

Continue reading “Experimental Drugs Target Bacteria’s Social Network”